Boldenone is an anabolic albeit naturally occurring male sex hormone, which is structurally related to the androstenol family of hormones. However, unlike testosterone, Boldenone cannot be metabolized by the liver. This is because only the testes can produce this hormone. As an androstenol, Boldenone behaves like an androstenone hormone, but its action is restricted to the lungs and testes, and thus, the production is much lower. Boldenone is most commonly used for men who have undergone bariatric surgery (weight loss), who are experiencing premature ejaculation or erectile dysfunction or for those who suffer from thyroid dysfunction.
Boldenone belongs to Boldenone a large family of chemicals called Nandrolone which are known to be beneficial for low testosterone levels and obesity as well. Boldenone is very similar in action to human growth hormone (HGH), which is known to have profound therapeutic effects on aging and weight management. Although HGH is naturally produced in the pituitary gland, HGH production can be stimulated by external factors, which include diet, puberty, fertility, estrogen and other hormones. HGH and Boldenone are closely related, and have recently come out of the labelling as nandrolone, as they have similar molecular structures. The only difference between Boldenone and HGH is that HGH is much more soluble in water and therefore can be easily passed into the blood stream where it acts on all cell membranes and organs, whereas Boldenone only gets dissolved in water and is excreted via urine.
Initially, doctors started using Boldenone in patients who had tried to lose weight, with mixed results. The initial increase in body weight was temporary and there were reports of side effects like muscle weakness, sexual dysfunctions and even acne in some cases. This was attributed to the binding of the anabolic hormone to the lipoprotein receptor sites in the liver. More studies in collaboration with several other pharmaceutical companies and other hormones were conducted to find out how this new hormone could be used in the treatment of overweight and obese men and women. It was found that there was a higher affinity for the Boldenone for the male hormone than for the female hormone. The result was a marked increase in body weight loss and decrease in fat mass and the increase in muscle size was also notable.
Later, in the year 2021, the Food and Drugs Administration (FDA) approved a generic version of Boldenone for the treatment of hypogonadism. Hypogonadism is characterized by an excess of circulating testosterone (often due to genetics). This condition affects approximately 5% of the population, so there had been plenty of time to try Boldenone and other anabolic steroids. However, it did not go well with all hypogonadism patients as evidenced by the mixed results with respect to safety, effectiveness, drug toxicity, and drug related lawsuits.
Currently Boldenone is being studied for its effects on protein synthesis, insulin sensitivity, and metabolism as well as increasing appetite. It is expected to have long-term benefits on these areas as well as on body weight loss. It has also been studied in combination with the widely known cortisone receptor antagonist immunomodulators (MAOIs) like Prednisone, Carfexol, and Lupercet. These medications all reduce the amount of protein synthesis and/or insulin sensitivity. As Boldenone is itself a mild anabolic (increase nitrogen retention) steroid it seems logical that it may have some similar long term benefits on those requiring muscular gain.
In August of 2021, after a lengthy investigation by the Florida Department of Health, Boldenone was tested positive for human growth hormone (HGH) in a non-verbal evaluation. According to a press release from the FDCHH, “the hormone Boldenone was confirmed as the primary applicant in the test.” Boldenone was found to have a half-life of approximately forty-five minutes, which is the length of time for which an over the counter substance will be active in a person. It is thought that this could account for why the testing showed no reaction in persons who had taken Boldenone previously.